| Bioactivity | Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation[1]. |
| Invitro | Mycro1(10 or 20 μM, 7 days)可以抑制 C-Myc 依赖细胞系 U-2OS、MCF-7、Raji 和 NIH/3T3 的增殖，不会抑制 C-Myc 独立癌细胞株 PC-12 的增殖。Mycro1 在 10 μM 时可以显著抑制 c- myc 诱导的基因转录，在 20 μM 时可以选择性减少 c- myc 转化Rat1a细胞的非锚定生长[1]。 |
| Name | Mycro1 |
| CAS | 313987-85-8 |
| Formula | C20H15F3N4O2S |
| Molar Mass | 432.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Anke Kiessling, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51. |