| Bioactivity | Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects[1][2]. | ||||||||||||
| Invitro | Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus[1].IMPDH is the rate-limiting enzyme in the de novo synthesis of guanosine nucleotides[2].Mycophenolic acid (0.01-1 μM; 72 hours) exhibits preferential antiproliferative activity against the endothelial cells and fibroblasts. Endothelial cells are most sensitive cells to Mycophenolic acid treatment with an IC50 1 μM. U87 glioblastoma cells are resistant against MPA treatment up to 1 μM[2].Mycophenolic acid (0.05-2 μM; 18 hours) exhibits a dose-dependent down-regulation of HDAC2 and MYC, whereas up-regulates NDRG1[2]. Cell Proliferation Assay[2] Cell Line: | ||||||||||||
| Name | Mycophenolic acid | ||||||||||||
| CAS | 24280-93-1 | ||||||||||||
| Formula | C17H20O6 | ||||||||||||
| Molar Mass | 320.34 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Mycophenolic acid
CAS: 24280-93-1 F: C17H20O6 W: 320.34
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24
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