| Bioactivity | Mycobacterial Zmp1-IN-1 is a mycobacterial zinc metalloprotease-1 (Zmp1) inhibitor. Mycobacterial Zmp1-IN-1 has anti-mycobacterial activity for Mtb H37Ra in dose-dependent inhibition. Mycobacterial Zmp1-IN-1 can be used for the research of tuberculosis (TB)[1]. |
| Invitro | Mycobacterial Zmp1-IN-1 (Compound 2f) has antimycobacterial activity for M. bovis and Mtb H37Ra in dose-dependent inhibition[1].Mycobacterial Zmp1-IN-1 has no acute cellular toxicity against the RAW 264.7 and MRC-5 cell line with IC50 values both of ＞128 μM[1].Mycobacterial Zmp1-IN-1 (8 μM, 32 μM, 128 μM) induces a reduction of bacterial survival within the macrophage host cell[1]. |
| Name | Mycobacterial Zmp1-IN-1 |
| Formula | C26H27N3O7S |
| Molar Mass | 525.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Milan Dak, et al. Novel heterocyclic hydroxamates as inhibitors of the mycobacterial zinc metalloprotease Zmp1 to probe its mechanism of function. Eur J Med Chem. 2022 Dec 15;244:114831. |
Mycobacterial Zmp1-IN-1
CAS: F: C26H27N3O7S W: 525.57
Mycobacterial Zmp1-IN-1 is a mycobacterial zinc metalloprotease-1 (Zmp1) inhibitor. Mycobacterial Zmp1-IN-1 has anti-myc
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