| Bioactivity | Mutabilol (compound 1) is a potent p-glycoprotein (P-gp) regulator. Mutabilol is a nature product could be isolated from Plectranthus mutabilis leaves. Mutabilol increases the P-gp expression in NCI-H460/R cells[1]. |
| Invitro | Mutabilol (compound 1; 2, 5, 10, 20, and 50 μM; 72 h) has low toxicity with IC50 values of >50, >50, and >50 μM for NCI-H460, NCI-H460/R, and MRC-5 cells, respectively[1].Mutabilol (5 and 10 μM; 72 h) stimulates P-gp activity by a direct interaction and decreases the Rho123 accumulation in NCI-H460/R cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | Mutabilol |
| Formula | C19H24O5 |
| Molar Mass | 332.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ntungwe EN, et al. C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators. ACS Med Chem Lett. 2022 Mar 11;13(4):674-680. |