| Bioactivity | Muscimol (Agarin; Agarine) hydrochloride is an isoxazole with psychoactive activity. Muscimol hydrochloride is also a selective agonist of the inhibitory neurotransmitter, GABA ionotropic receptors. Muscimol hydrochloride can be isolated from from Amanita muscaria and related mushrooms. All in all, Muscimol is a potent GABAA receptors agonist (EC50=0.2 μM), a partial GABACreceptors agonist, and an inactive GABAB receptors agonist. Muscimol hydrochloride has calming, anti-anxiety and hallucinatory effects[1]. |
| Target | EC50: 0.2 μM (GABACreceptors) |
| In Vivo | Muscimol 影响前额叶皮层的功能，并且在注射到腹侧前额叶皮层后（1μL，5μg/μL；前额叶皮层输注），损害猴子在计数任务中的表现，但在注射到背侧前额叶皮层后没有影响[2]。Muscimol 影响前扣带皮层 (ACC) 的微量调节，并且在 10 秒微量组中（62.5 或 125 µg/侧）对抑制噪声刺激没有影响[3]。 Animal Model: |
| Name | Muscimol hydrochloride |
| CAS | 3579-03-1 |
| Formula | C4H7ClN2O2 |
| Molar Mass | 150.56 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Johnston GA. Muscimol as an ionotropic GABA receptor agonist. Neurochem Res. 2014 Oct;39(10):1942-7. [2]. Sun W, et al. Muscimol-induced inactivation of the ventral prefrontal cortex impairs counting performance in rhesus monkeys. Sci Prog. 2022 Oct-Dec;105(4):368504221141660. [3]. Pezze MA, et al. Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat. J Psychopharmacol. 2020 Dec;34(12):1457-1460. |
Muscimol hydrochloride
CAS: 3579-03-1 F: C4H7ClN2O2 W: 150.56
Muscimol (Agarin; Agarine) hydrochloride is an isoxazole with psychoactive activity. Muscimol hydrochloride is also a se
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