| Bioactivity | Multi-Leu peptide (ML-peptide, Multi-Leucine (ML)-peptide) is a potent inhibitor of PACE4 (Ki=22 nM). Multi-Leu peptide can competitively bind to the active site of PACE4 by simulating the substrate sequence of PACE4, thereby inhibiting its catalytic activity. Multi-Leu peptide can be used to study the specific mechanism of PACE4 in the development of prostate cancer[1]. |
| CAS | 1413058-07-7 |
| Sequence | Ac-Leu-Leu-Leu-Leu-Arg-Val-Lys-Arg-NH2 |
| Shortening | Ac-LLLLRVKR-NH2 |
| Formula | C49H94N16O9 |
| Molar Mass | 1051.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Łepek T, et al. Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations[J]. European journal of cell biology, 2017, 96(5): 476-485. |
Multi-Leu peptide
CAS: 1413058-07-7 F: C49H94N16O9 W: 1051.37
Multi-Leu peptide (ML-peptide, Multi-Leucine (ML)-peptide) is a potent inhibitor of PACE4 (Ki=22 nM). Multi-Leu peptide
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