| Bioactivity | Mtb-cyt-bd oxidase-IN-7 is a cytochrome bd terminal oxidase (Cyt-bd) inhibitor with a Kd value of 4.17 μM. Mtb-cyt-bd oxidase-IN-7 shows anti-tuberculosis activities[1]. |
| Invitro | Mtb-cyt-bd oxidase-IN-7 (compound 8d) 是一种 1-hydroxy-2-methylquinolin-4(1H)-one 衍生物。Mtb-cyt-bd oxidase-IN-7 抑制细胞色素 bcc-aa3 氧化酶 (Cyt-bcc) 敲除菌株 (ΔqcrCAB, Cyt-bd+) 的生长，MIC 值为 6.25 μM。Mtb-cyt-bd oxidase-IN-7与 Cyt-bcc 抑制剂 Q203 的组合完全抑制了野生型菌株和表达结核分枝杆菌 Cyt-bd (ΔcydAB::MtbCydAB+) 的倒膜囊泡的耗氧量[1]。 |
| Name | Mtb-cyt-bd oxidase-IN-7 |
| Formula | C18H14F3NO2 |
| Molar Mass | 333.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang Zhou, et al. Discovery of 1-hydroxy-2-methylquinolin-4(1H)-one derivatives as new cytochrome bd oxidase inhibitors for tuberculosis therapy. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114896. |
Mtb-cyt-bd oxidase-IN-7
CAS: F: C18H14F3NO2 W: 333.30
Mtb-cyt-bd oxidase-IN-7 is a cytochrome bd terminal oxidase (Cyt-bd) inhibitor with a Kd value of 4.17 μM. Mtb-cyt-bd o
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.