Mtb-IN-4_product_DataBase

Bioactivity	Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC50=0.70 μM). Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant[1].
Target	Mycobacterium tuberculosis (Mtb)
Invitro	Mtb-IN-4 有效地使 Mtb katG 突变体对 INH 的抑制重新敏感[1]。Mtb-IN-4 抑制小鼠 RAW 264.7 巨噬细胞内 Mtb 的生长，IC50 为 3.467 μM[1]。 0 --> Mtb-IN-4 相关抗体:
Name	Mtb-IN-4
CAS	2306039-13-2
Formula	C24H18N2O4S
Molar Mass	430.48
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sarkar S, et al. Design, Synthesis, and Evaluation of Novel Δ2-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant. J Med Chem. 2023 Aug 24;66(16):11056-11077.

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