| Bioactivity | MtTMPK-IN-3 (compound 25) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 0.12 μM. MtTMPK-IN-3 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-3 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 12.5 μM). MtTMPK-IN-3 can be used for researching tuberculosis[1]. |
| Target | IC50: 0.12 μM (MtbTMPK) |
| Name | MtTMPK-IN-3 |
| CAS | 2799607-80-8 |
| Formula | C23H23Cl2N3O3 |
| Molar Mass | 460.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Song L, et al. Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors. Eur J Med Chem. 2021;225:113784. |
MtTMPK-IN-3
CAS: 2799607-80-8 F: C23H23Cl2N3O3 W: 460.35
MtTMPK-IN-3 (compound 25) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 valu
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