| Bioactivity | MtMetAP1-IN-1 is an inhibitor of Mycobacterium tuberculosis (Mtb), targeting methionine aminopeptidase 1 (MetAP1). MtMetAP1-IN-1 exerts antimycobacterial activity[1]. |
| Target | methionine aminopeptidase 1 (MetAP1) |
| Invitro | MetAP1 is known to work in the presence of various divalent cations, is considered to acts function with a most probable cofactor, iron (Fe2+)[1]. MtMetAP1-IN-1 (compound 12) (12.5 μM) inhibits MtMetAP1 under different metals catalytic effect with residual activity RA (%) of 51% (Co2+), 21% (Ni2+), 33% (Fe2+)[1]. MtMetAP1-IN-1 has a preference towards Ni2+, inhibits MtMetAP1 with an IC50 value of with 0.7 μM [1]. |
| Name | MtMetAP1-IN-1 |
| Formula | C15H10BrN5O2S |
| Molar Mass | 404.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Juhás M, et al. Design, synthesis and biological evaluation of substituted 3-amino-N-(thiazol-2-yl)pyrazine-2-carboxamides as inhibitors of mycobacterial methionine aminopeptidase 1. Bioorg Chem. 2022 Jan;118:105489. |