| Bioactivity | Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 5.48 μM. Mt KARI-IN-4 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 72 μg/mL)[1]. |
| Target | Ki: 5.48 μM (Mtb KARI) |
| Name | Mt KARI-IN-4 |
| CAS | 2413974-53-3 |
| Formula | C13H8FN5O3S2 |
| Molar Mass | 365.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178. |
Mt KARI-IN-4
CAS: 2413974-53-3 F: C13H8FN5O3S2 W: 365.36
Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with
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