MrgprX2 antagonist-3_product_DataBase

Bioactivity	MrgprX2 antagonist-3 is an MrgprX2 antagonist extracted from patent WO2021092240A1, example E117. MrgprX2 antagonist-3 can be used for the research of inflammatory disorders of the skin[1].
Target	MrgprX2
Invitro	MRGPRX2, a member of the Mas-related gene family, was found to be expressed in sensory neurons, mast cells and, most recently, in keratinocytes. MRGPRX2 mRNA is present in adipose tissue, esophagus, urinary bladder, lungs with the highest levels found in skin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions[2].
Name	MrgprX2 antagonist-3
CAS	2642174-19-2
Formula	C16H20FN3O2S
Molar Mass	337.41
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. CEVIKBAS F, et, al. Mrgprx2 antagonists for the treatment of inflammatory disorders. WO2021092240A1. [2]. Porebski G, et, al. Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions. Front Immunol. 2018 Dec 20;9:3027.

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