| Bioactivity | MreB Perturbing Compound A22 hydrochloride is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly. MreB Perturbing Compound A22 hydrochloride blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC=3.1 µg/ml). | |||||||||
| Name | MreB Perturbing Compound A22 hydrochloride | |||||||||
| CAS | 22816-60-0 | |||||||||
| Formula | C8H9Cl3N2S | |||||||||
| Molar Mass | 271.59 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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| Reference | [1]. Zemer Gitai, et al. MreB actin-mediated segregation of a specific region of a bacterial chromosome. Cell. 2005 Feb 11;120(3):329-41. [2]. Noritaka Iwai, et al. Novel S-benzylisothiourea compound that induces spherical cells in Escherichia coli probably by acting on a rod-shape-determining protein(s) other than penicillin-binding protein 2. Biosci Biotechnol Biochem. 2002 Dec;66(12):2658-62. |
MreB Perturbing Compound A22 hydrochloride
CAS: 22816-60-0 F: C8H9Cl3N2S W: 271.59
MreB Perturbing Compound A22 hydrochloride is a benzylisothiourea compound that interacts with the ATP binding site of M
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