| Bioactivity | Mps1-IN-5 is a potent and orally active Mps1 inhibitor with an IC50 value of 29 nM. Mps1-IN-5 induces Apoptosis and cell cycle arrests at G2/M phase. Mps1-IN-5 shows antiproliferative activity and anti-tumor activity. Mps1-IN-5 inhibits phosphorylation of Mps1 and induces DNA damage[1]. |
| Invitro | Mps1-IN-5 (compound 12) (0-10 µM,24, 48, 72 h) 以时间依赖性方式抑制 MCF-7 和 4T1 细胞的增殖[1].Mps1-IN-5 (0, 0.5, 1.0, 5.0 µM; 24, 48 h) 在 MCF-7 和 4T1 细胞中以剂量依赖性方式诱导细胞凋亡和胞周期停滞在 G2/M 期[1] .Mps1-IN-5 (0, 0.03, 0.1, 1, 3 µM; 2 h) 抑制 Mps1 的磷酸化并诱导 DNA 损伤[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | Mps1-IN-5 |
| Formula | C24H25N9 |
| Molar Mass | 439.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |