| Bioactivity | Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities[1][2]. |
| Invitro | 在 SH-SY5Y 人神经母细胞瘤细胞中，Moringin（16.4 µM；24-72 小时）以时间和浓度依赖性方式显着降低 SH-SY5Y 细胞生长[2]。Moringin (1.64-8.2 μM; 24 h) 在 SH-SY5Y 细胞中增加 p53、p21 和 Bax 在蛋白质和转录水平的表达。 Moringin 显著增加 caspase 3/9 的基因表达并增强它们的切割，从而启动内在的细胞凋亡级联反应[2]。Moringin 抑制 NF-κB 的核转位[2]。 |
| Name | Moringin |
| CAS | 73255-40-0 |
| Formula | C14H17NO5S |
| Molar Mass | 311.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |