Moracin C_product_DataBase

Bioactivity	Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells[1].
Invitro	Moracin C (1-50 μM，24 小时) 抑制 RAW264.7 细胞释放 LPS 激活的活性氧 (ROS) 和一氧化氮 (NO)[1]。Moracin C (1-50 μM, 2 h) 抑制 RAW264.7 细胞中 iNOS 和 COX-2 的 mRNA 和蛋白表达[1]。Moracin C (1-50 μM，2 小时) 抑制 LPS 激活的 RAW 264.7 细胞中促炎细胞因子 (IL-1β、IL-6 和 TNF-α) 的产生[1]。Moracin C (1-50 μM，2 小时) 抑制 LPS 激活的 RAW 264.7 细胞中 p38、ERK 和 JNK 的磷酸化[1]。 RT-PCR[1] Cell Line:
In Vivo	Moracin C (100 mg/kg，灌胃，小鼠) 在肠道内吸收迅速、吸收良好，在胃肠道、肝脏、肾脏和肺部分布较广[2]。 Animal Model:
Name	Moracin C
CAS	69120-06-5
Formula	C19H18O4
Molar Mass	310.34
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Yao X, et al. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci. 2016 Jul 25;17(8):1199. [2]. You BH, et al. Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Jul;87(8):642-651.

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