Monatepil maleate_product_DataBase

Bioactivity	Monatepil maleate (AJ-2615) is a potent and orally active Ca2+-channel antagonist and a noncompetitive ACAT inhibitor. Monatepil maleate decreases blood pressure and improves plasma lipid metabolism. Monatepil maleate has the potential for the research of hyperlipidemia[1][2].
In Vivo	Monatepil maleate (30 mg/kg; p.o.; once daily for 9 weeks) 可改善血浆脂质代谢[1]。Monatepil maleate (30 mg/kg; p.o.; once daily for 6 weeks) 可抑制高胆固醇饮食猴子的 ACAT 活性和酯化胆固醇含量[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	103379-03-9
Formula	C32H34FN3O5S
Molar Mass	591.69
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ikeno A, et al. Effects of monatepil maleate, a new Ca2+ channel antagonist with alpha1-adrenoceptor antagonistic activity, on cholesterol absorption and catabolism in high cholesterol diet-fed rabbits. Jpn J Pharmacol. 1998 Nov;78(3):303-12. [2]. Sumiya T, et al. Inhibitory effect of monatepil maleate on acyl-CoA:cholesterol acyltransferase activity in the liver of cholesterol-fed Japanese monkeys. Am J Hypertens. 1997 Jul;10(7 Pt 1):779-85.

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