| Bioactivity | Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3]. |
| Invitro | Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM)[3].Monactin inhibits TCF/β-catenin transcriptional activity[4].At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+)[5]. |
| Name | Monactin |
| CAS | 7182-54-9 |
| Formula | C41H66O12 |
| Molar Mass | 750.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |