Momordicoside G_product_DataBase

Bioactivity	Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury[1].
Invitro	用 10 ng/mL LPS 或 10 ng/mL IL-10 刺激 Raw264.7 巨噬细胞 24 h，获得 M1 样 (iNOS+) 和 M2样 (精氨酸酶+) 巨噬细胞[1]。Momordicoside G (10-40 μM; 24 h) 抑制 M1 巨噬细胞的细胞活力，对 M2 巨噬细胞无抑制作用。Momordicoside G (40 μM) 体外诱导 M1 巨噬细胞凋亡，降低 NO 水平，增加 IL-12、IL-10 和 TGF-β 水平[1]。Momordicoside G (40 μM) 可抑制细胞自噬相关标志物 LC3-B 的蛋白水平[1]。 Cell Viability Assay[1] Cell Line:
Name	Momordicoside G
CAS	81371-54-2
Formula	C37H60O8
Molar Mass	632.87
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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