| Bioactivity | Modotuximab (Anti-Human EGFR Recombinant Antibody) is an IgG1κ-type chimeric antibody targeting human EGFR protein. Modotuximab contains a portion of Futuximab that binds to two independent, non-overlapping epitopes on EGFR. Modotuximab promotes cross-linking of EGFR on the cell surface and promotes EGFR cellular internalization and degradation. Modotuximab has antitumor activity in vivo[1]. |
| Name | Modotuximab |
| CAS | 1310460-86-6 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. KeirST, et al. Sym004-induced EGFRelimination is associated with profound anti-tumor activity in EGFRvIIIpatient-derived glioblastoma models. J Neurooncol. 2018 Jul;138(3):489-498. [2]. Modotuximab. IMGT Database. |