| Bioactivity | Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1]. | ||||||||||||
| Target | IC50: 3.8 nM (Glucocorticoid receptor). | ||||||||||||
| In Vivo | Mizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation[1]. Animal Model: | ||||||||||||
| Name | Mizacorat | ||||||||||||
| CAS | 1893415-00-3 | ||||||||||||
| Formula | C27H28F2N4O3 | ||||||||||||
| Molar Mass | 494.53 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Ripa L, et al. Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J Med Chem. 2018 Mar 8;61(5):1785-1799. |
Mizacorat
CAS: 1893415-00-3 F: C27H28F2N4O3 W: 494.53
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator
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