Mitochondrial respiration-IN-3_product_DataBase

Bioactivity	Mitochondrial respiration-IN-3 is the fluorine derivative of Dalfopristin (HY-A0241). Mitochondrial respiration-IN-3 has cell membrane-permeable. Mitochondrial respiration-IN-3 can inhibit mitochondrial translation of glioblastoma stem cells. Mitochondrial respiration-IN-3 can be used in research of cancer[1].
Invitro	Mitochondrial respiration-IN-3 ((16R)-1e; 48 h; COMI 细胞) 抑制细胞生长，GI50 值为 6.73 μM[1]。Mitochondrial respiration-IN-3 (100 μM; 3 h; COMI 细胞) 具有良好的细胞膜渗透性，与 Dalfopristin 相比增加了渗透性[1]。Mitochondrial respiration-IN-3 (0-5 μM; 48 h; COMI 细胞) 以剂量依赖性方式抑制线粒体翻译[1]。
Name	Mitochondrial respiration-IN-3
Formula	C35H51FN4O7S
Molar Mass	690.87
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sighel D, et, al. Streptogramin A derivatives as mitochondrial translation inhibitors to suppress glioblastoma stem cell growth. Eur J Med Chem. 2023 Jan 15;246:114979.

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