| Bioactivity | MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy[1]. |
| Target | Thioredoxin reductase 2 (TrxR2) |
| Invitro | MitoCur-1对 HepG2 和 L02 细胞具有选择性细胞毒性，IC50 分别为 1.4 μM 和 9.1 μM[1]。MitoCur-1 (10 μM; 12 h) 在 HepG2 细胞中产生 ROS 并选择性地消耗 GSH[1]。MitoCur-1 (10 μM; 24 h) 阻滞 G0/G1 期细胞周期，抑制细胞周期蛋白表达[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | MitoCur-1 (5 mg/kg，15 mg/kg；腹腔注射; 每隔天施用一次，共 4 周) 抑制小鼠模型肿瘤生长，对体重无影响[1]。 Animal Model: |
| Name | MitoCur-1 |
| Formula | C65H64Cl2O6P2 |
| Molar Mass | 1074.05 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Zheng YL, et al. Redox-Based Strategy for Selectively Inducing Energy Crisis Inside Cancer Cells: An Example of Modifying Dietary Curcumin to Target Mitochondria. J Agric Food Chem. 2022 Mar 9;70(9):2898-2910. |