| Bioactivity | MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70[1]. | ||||||||||||
| Invitro | MB-10 (100 μM) is a potential attenuator of protein import into mitochondria[1].MB-10 inhibits the import of substrates that use the TIM23 import pathway[1].MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | MitoBloCK-10 | ||||||||||||
| CAS | 394694-98-5 | ||||||||||||
| Formula | C12H8FN3O3S | ||||||||||||
| Molar Mass | 293.27 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442. |
MitoBloCK-10
CAS: 394694-98-5 F: C12H8FN3O3S W: 293.27
MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
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