| Bioactivity | MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC50 values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation[1]. |
| Name | MitTx |
| Sequence | Chain1: {Pyr}-Ile-Arg-Pro-Ala-Phe-Cys-Tyr-Glu-Asp-Pro-Pro-Phe-Phe-Gln-Lys-Cys-Gly-Ala-Phe-Val-Asp-Ser-Tyr-Tyr-Phe-Asn-Arg-Ser-Arg-Ile-Thr-Cys-Val-His-Phe-Phe-Tyr-Gly-Gln-Cys-Asp-Val-Asn-Gln-Asn-His-Phe-Thr-Thr-Met-Ser-Glu-Cys-Asn-Arg-Val-Cys-His-Gly (Disulfide bridge: Cys7-Cys54; Cys17-Cys41; Cys33-Cys58); Chain2: Asn-Leu-Asn-Gln-Phe-Arg-Leu-Met-Ile-Lys-Cys-Thr-Asn-Asp-Arg-Val-Trp-Ala-Asp-Phe-Val-Asp-Tyr-Gly-Cys-Tyr-Cys-Val-Ala-Arg-Asp-Ser-Asn-Thr-Pro-Val-Asp-Asp-Leu-Asp-Arg-Cys-Cys-Gln-Ala-Gln-Lys-Gln-Cys-Tyr-Asp-Glu-Ala-Val-Lys-Val-His-Gly-Cys-Lys-Pro-Leu-Val-Met-Phe-Tyr-Ser-Phe-Glu-Cys-Arg-Tyr-Leu-Ala-Ser-Asp-Leu-Asp-Cys-Ser-Gly-Asn-Asn-Thr-Lys-Cys-Arg-Asn-Phe-Val-Cys-Asn-Cys-Asp-Arg-Thr-Ala-Thr-Leu-Cys-Ile-Leu-Thr-Ala-Thr-Tyr-Asn-Arg-Asn-Asn-His-Lys-Ile-Asp-Pro-Ser-Arg-Cys-Gln (Disulfide bridge: Cys11-Cys70; Cys25-Cys118; Cys27-Cys43; Cys42-Cys100; Cys49-Cys93; Cys59-Cys86; Cys79-Cys91) |
| Shortening | Chain1: {Pyr}-IRPAFCYEDPPFFQKCGAFVDSYYFNRSRITCVHFFYGQCDVNQNHFTTMSECNRVCHG (Disulfide bridge: Cys7-Cys54; Cys17-Cys41; Cys33-Cys58); Chain2: NLNQFRLMIKCTNDRVWADFVDYGCYCVARDSNTPVDDLDRCCQAQKQCYDEAVKVHGCKPLVMFYSFECRYLASDLDCSGNNTKCRNFVCNCDRTATLCILTATYNRNNHKIDPSRCQ (Disulfide bridge: Cys11-Cys70; Cys25-Cys118; Cys27-Cys43; Cys42-Cys100; Cys49-Cys93; Cys59-Cys86; Cys79-Cys91) |
| Formula | C899H1331N259O271S23 |
| Molar Mass | 20840.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bohlen CJ, et al. A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature. 2011 Nov 16;479(7373):410-4. |