| Bioactivity | Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (KD: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II[1]. |
| Invitro | Miptenalimab 阻断可溶性 hLAG-3 与表达 MHC-II 的 Raji 细胞的结合 (IC90: 2.1 nM)[1]。Miptenalimab 增加小鼠细胞系 3A9-hLAG-3 的 IL-2 分泌 (EC50: 0.31 nM)，同时增加 IFN-γ 分泌[1]。 |
| Name | Miptenalimab |
| CAS | 2249882-55-9 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zettl M, et al. Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses. Oncoimmunology. 2022 Jun 16;11(1):2080328. |