Minnelide free base_product_DataBase

Bioactivity	Minnelide free base is a prodrug of Triptolide (HY-32735) that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide free base promotes apoptosis[1].
Invitro	Minnelide (0-200 nM；48 小时) free base 在存在磷酸酶的情况下处理后，胰腺癌细胞系的细胞活力显著降低，但在不存在磷酸酶的情况下则没有降低[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Minnelide free base 相关抗体:
In Vivo	Minnelide (腹膜内注射；0.1-0.6 mg/kg；每日一次或每日两次) free base 导致治疗结束时肿瘤重量和体积显着减少，并增加 MIA PaCa-2 衍生的人类胰腺肿瘤的胰腺癌原位模型的生存率[2]。Minnelide (腹膜内注射；0.42 mg/kg；每日一次；28 天) free base 可防止局部扩散，并导致转移性 S2-013 细胞的胰腺癌异种移植模型的平均肿瘤重量下降[2]。Minnelide (腹膜内注射；0.42 mg/kg、0.21 mg/kg；每日一次) free base 导致 SCID 小鼠中的异种移植肿瘤消退，表现出纤维化和固缩核[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1254885-39-6
Formula	C21H27O10P
Molar Mass	470.41
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Noel P, et al. Triptolide and Its Derivatives as Cancer Therapies. Trends Pharmacol Sci. 2019 May;40(5):327-341. [2]. Chugh R, et al. A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer. Sci Transl Med. 2012 Oct 17;4(156):156ra139.

PeptideDB

Minnelide free base

CAS: 1254885-39-6 F: C21H27O10P W: 470.41