| Bioactivity | Milademetan tosylate is the tosylate salt form of Milademetan (HY-101266). Milademetan tosylate is an orally active inhibitor for MDM2. Milademetan tosylate arrests the cell cycle at G1 pahse, induces the apoptosis Milademetan tosylate restores the p53 activity by targeting the p53-MDM2 interaction, and exhibits anticancer activity against Merkel cell carcinoma (MCC)[1]. |
| CAS | 1398569-75-9 |
| Formula | C37H42Cl2FN5O7S |
| Molar Mass | 790.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ananthapadmanabhan V, et al., Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma. JCI Insight. 2022 Jul 8;7(13):e160513. |
Milademetan tosylate
CAS: 1398569-75-9 F: C37H42Cl2FN5O7S W: 790.73
Milademetan tosylate is the tosylate salt form of Milademetan (HY-101266). Milademetan tosylate is an orally active inhi
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