| Bioactivity | Microtubule inhibitor 12 (Compound 2k) is an inhibitor for microtubule polymerization with an IC50 of 22.23 μM. Microtubule inhibitor 12 arrests the cell cycle of B16-F10 at G2/M phase, induces apoptosis in B16-F10, and inhibits cell migration. Microtubule inhibitor 12 inhibits the proliferation of cancer cells B16-f10, A549, HepG2 and MCF-7, with IC50s of 0.098, 0.135, 0.109, and 0.259 μM, respectively. Microtubule inhibitor 12 exhibits antitumor efficacy in mouse model[1]. |
| Target | IC50: 22.23 μM (microtubule polymerization) |
| Formula | C22H22N4O3 |
| Molar Mass | 390.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lin RJ, et al., Design, synthesis and anti-tumor evaluation of novel pyrimidine and quinazoline analogues. Eur J Med Chem. 2025 Jan 15;282:117057. |
Microtubule inhibitor 12
CAS: F: C22H22N4O3 W: 390.44
Microtubule inhibitor 12 (Compound 2k) is an inhibitor for microtubule polymerization with an IC50 of 22.23 μM. Microtu
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