| Bioactivity | Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively. |
| Invitro | Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication[2]. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration[1]. |
| Name | Microcystin-LR |
| CAS | 101043-37-2 |
| Shortening | ADALD-{Bas}-R-{Oaa}-D-{Ggu} |
| Formula | C49H74N10O12 |
| Molar Mass | 995.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Microcystin-LR
CAS: 101043-37-2 F: C49H74N10O12 W: 995.17
Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and
Data collection：peptidedb@qq.com
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