| Bioactivity | Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex[1]. | ||||||||||||
| Invitro | Miclxin (0-15 μM; 48 h) 抑制 β-catenin 突变的 HCT116 细胞和等基因 HCT116 细胞 (CTNNB1 Δ45/-) 的生长，(10 μM; 24 h) 诱导 HCT116 细胞凋亡[1]。 Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | Miclxin | ||||||||||||
| CAS | 2494198-61-5 | ||||||||||||
| Formula | C26H27N5O2 | ||||||||||||
| Molar Mass | 441.52 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Ikeda H, et al. Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells. ACS Chem Biol. 2020 Aug 21;15(8):2195-2204. |