| Bioactivity | Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors. | ||||||||||||
| In Vivo | Incubation of Mibampator (LY451395) with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species [1]. LY404187 and Mibampator (LY451395) reverses the central effects of an acutely intoxicating dose of ethanol in the rat. Mibampator (LY451395) significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward [2]. | ||||||||||||
| Name | Mibampator | ||||||||||||
| CAS | 375345-95-2 | ||||||||||||
| Formula | C21H30N2O4S2 | ||||||||||||
| Molar Mass | 438.60 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Zmijewski M, et al. Application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis. Drug Metab Dispos. 2006 Jun;34(6):925-31. [2]. Jones N, et al. AMPA receptor potentiation can prevent ethanol-induced intoxication. Neuropsychopharmacology. 2008 Jun;33(7):1713-23. |