Methylproamine_product_DataBase

Bioactivity

Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks[1].

Invitro

Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks[1].Methylproamine can protect bystander cells from radiation-induced DNA damage[2].Methylproamine has a concentration-dependent radioprotective effect[3] Cell Cytotoxicity Assay[3] Cell Line:

Name

Methylproamine

CAS

188247-01-0

Formula

C28H31N7

Molar Mass

465.59

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Carl N Sprung, et al. Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. [2]. Susanne Burdak-Rothkamm, et al. Radioprotection of targeted and bystander cells by methylproamine. Strahlenther Onkol. 2015 Mar;191(3):248-55. [3]. Pavel N Lobachevsky, et al. Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83. [4]. Lobachevsky PN, Vasireddy RS, Broadhurst S, Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83. [5]. Sprung CN, Vasireddy RS, Karagiannis TC, Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. Mutat Res. 2010 Oct 13;692(1-2):49-52. [6]. Martin RF, Broadhurst S, Reum ME, In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 2004 Feb 1;64(3):1067-70.

PeptideDB

Methylproamine

CAS: 188247-01-0 F: C28H31N7 W: 465.59