| Bioactivity | Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks[1]. | ||||||||||||
| Invitro | Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks[1].Methylproamine can protect bystander cells from radiation-induced DNA damage[2].Methylproamine has a concentration-dependent radioprotective effect[3] Cell Cytotoxicity Assay[3] Cell Line: | ||||||||||||
| Name | Methylproamine | ||||||||||||
| CAS | 188247-01-0 | ||||||||||||
| Formula | C28H31N7 | ||||||||||||
| Molar Mass | 465.59 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Carl N Sprung, et al. Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. [2]. Susanne Burdak-Rothkamm, et al. Radioprotection of targeted and bystander cells by methylproamine. Strahlenther Onkol. 2015 Mar;191(3):248-55. [3]. Pavel N Lobachevsky, et al. Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83. [4]. Lobachevsky PN, Vasireddy RS, Broadhurst S, Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83. [5]. Sprung CN, Vasireddy RS, Karagiannis TC, Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. Mutat Res. 2010 Oct 13;692(1-2):49-52. [6]. Martin RF, Broadhurst S, Reum ME, In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 2004 Feb 1;64(3):1067-70. |
Methylproamine
CAS: 188247-01-0 F: C28H31N7 W: 465.59
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA.
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