Methylergometrine_product_DataBase

Bioactivity	Methylergometrine (Methylergonovine) is an orally active 5-HT2B ligand agonist. The distribution half-life of Methylergometrine is only 1-2 min. Methylergometrine can be used as an oxytocin to treat uterine atony[1][2][3].
In Vivo	Methylergometrine (0.2 mg/kg；静脉注射；单剂量) 出现在家兔子宫、肝脏和肾脏中，平均浓度分别为 34 ng/g、80 ng/g 和 203 ng/g (给药 30 min 后)[3]。Methylergometrine 在家兔中的药代动力学 (PK) 参数[3]
Name	Methylergometrine
CAS	113-42-8
Formula	C20H25N3O2
Molar Mass	339.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hajjo R, et al. Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs. J Med Chem. 2010 Nov 11;53(21):7573-86. [2]. Amant F, et al. Misoprostol compared with methylergometrine for the prevention of postpartum haemorrhage: a double-blind randomised trial. Br J Obstet Gynaecol. 1999 Oct;106(10):1066-70. [3]. Mäntylä R, et al. Plasma and tissue concentrations of methylergometrine (methylergonovine) in the rabbit. Acta Pharmacol Toxicol (Copenh). 1980 Apr;46(4):245-9.

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