Methyl gerfelin_product_DataBase

Bioactivity	Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class[1][2].
Target	Glyoxalase 1 (GLO1), Sterol binding protein 2 (SCP2), Small glutamine-rich tetratricopeptide repeat containing protein A (SGTA)
Invitro	Methyl gerfelin (0-30 μM; 72 h) 抑制破骨细胞形成，IC50 为 2.8 μM，有效浓度下不影响成熟破骨细胞存活和功能[1]。
Name	Methyl gerfelin
CAS	700870-56-0
Formula	C16H16O6
Molar Mass	304.29
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kanoh N, et al. Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning. Bioconjug Chem. 2013 Jan 16;24(1):44-52. [2]. Perez C, et al. Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem. 2019 Feb 14;62(3):1609-1625.

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