| Bioactivity | Methylcellulose is a natural polymer which gels on heating. Methylcellulose is not toxic. | ||||||
| In Vivo | Protocal for preparing 0.5% Methylcellulose SolutionMeasure 0.5g of dry Methylcellulose and dissolved in 100 ml ddH2O/0.9% Saline (0.9 g NaCl in 100 ml ddH2O) to make a clear solution. Under the condition of stirring and heating (50-65°C), adding Methylcellulose slowly to ddH2O/0.9% Saline helps to accelerate dissolution. Note1.You must ensure that your Methylcellulose solution does not exist solid-liquid separation phenomenon. The solution is in a uniform and transparent state has no particles in it.2.Completely dissolution of Methylcellulose may requires 4 hours or more longer.0.5% Methylcellulose solution (0.5% MC) can be used for oral adminstration or intraperitoneal injection[1]. | ||||||
| Name | Methyl cellulose | ||||||
| CAS | 9004-67-5 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage |
|
||||||
| Reference | [1]. Stacey Meeker, et al. Repeated Intraperitoneal Administration of Low-Concentration Methylcellulose Leads to Systemic Histologic Lesions Without Loss of Preclinical Phenotype. J Pharmacol Exp Ther. 2019 Oct;371(1):25-35 |