Metallo-β-lactamase-IN-9

CAS: F: C13H12N6O3S W: 332.34

Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC50s of 35, 269 and 369 nM

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC50s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively[1].
Target	IC50: 35 nM (NDM-1), 269 nM (VIM-1), 369 nM (IMP-1)
In Vivo	Metallo-β-lactamase-IN-9 (Compound 23) (10 and 50 mg/kg; s.c.; three times a day for 1 day) 在小鼠 Klebsiella pneumoniae MB9249 感染模型中与 Imipenem (HY-B1369A) 联用减少脾脏和肾脏的细菌负担[1]。Mouse Pharmacokinetic Properties of Metallo-β-lactamase-IN-9 (Compound 23)d[1] dosea(iv, mpk)
Name	Metallo-β-lactamase-IN-9
Formula	C13H12N6O3S
Molar Mass	332.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mandal M, et al. Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates. J Med Chem. 2022 Dec 22;65(24):16234-16251.

Amastatin hydrochloride