Bioactivity | Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC50 values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively[1]. |
Invitro | Metallo-β-lactamase-IN-15 (Compound ±13) (50 μg/mL; 100 μg/mL) 对 L929 细胞无毒性[1]。Metallo-β-lactamase-IN-15 具有良好的生物利用度和血浆稳定性[1]。Metallo-β-lactamase-IN-15 (100 μg/mL;1、3、5h)对表达 NDM-1 的大肠杆菌 DH5α 菌株生长的活性测试,Metallo-β-lactamase-IN-15 恢复了亚胺培南的体外活性[1]。Metallo-β-lactamase-IN-15 (100 μg/mL) 能降低临床大肠杆菌 DH5α 菌株的美罗培南的最低抑制浓度[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Metallo-β-lactamase-IN-15 相关抗体: Cell Line: |
CAS | 1804934-57-3 |
Formula | C10H11NS3 |
Molar Mass | 241.40 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Villamil, Valentina et al. “Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.” Journal of medicinal chemistry, 19 Feb. 2024. |