Metallo-β-lactamase-IN-15_product_DataBase

Bioactivity	Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC50 values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively[1].
Invitro	Metallo-β-lactamase-IN-15 (Compound ±13) (50 μg/mL; 100 μg/mL) 对 L929 细胞无毒性[1]。Metallo-β-lactamase-IN-15 具有良好的生物利用度和血浆稳定性[1]。Metallo-β-lactamase-IN-15 (100 μg/mL；1、3、5h）对表达 NDM-1 的大肠杆菌 DH5α 菌株生长的活性测试，Metallo-β-lactamase-IN-15 恢复了亚胺培南的体外活性[1]。Metallo-β-lactamase-IN-15 (100 μg/mL) 能降低临床大肠杆菌 DH5α 菌株的美罗培南的最低抑制浓度[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Metallo-β-lactamase-IN-15 相关抗体: Cell Line:
CAS	1804934-57-3
Formula	C10H11NS3
Molar Mass	241.40
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Villamil, Valentina et al. “Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.” Journal of medicinal chemistry, 19 Feb. 2024.

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