| Bioactivity | Metallo-β-lactamase-IN-12 is a dual inhibitor of metal β-lactamases (MβLs (NDM-1, IMP-1)) and serine β-lactamases (SβLs (OXA-48, KPC-2)), with IC50 values of 0.64 μM, 1.32 μM, 1.01 μM, and 0.57 μM, respectively. Metallo-β-lactamase-IN-12 has antibacterial activity[1]. |
| Target | IC50: 0.64 μM (NDM-1). IC50: 1.32 μM (IMP-1). IC50: 1.01 μM (OXA-48). IC50: 0.57 μM (KPC-2). |
| Name | Metallo-β-lactamase-IN-12 |
| Formula | C18H19NO4 |
| Molar Mass | 313.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu XR, et al. Discovery of hydroxamate as a promising scaffold dually inhibiting metallo- and serine-β-lactamases. Eur J Med Chem. 2023 Dec 16;265:116055. |