Mephenytoin-13C,d3

CAS: 1261398-53-1 F: C1113CH11D3N2O2 W: 222.26

Mephenytoin-13C,d3 is a deuterated labeled Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substr

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Bioactivity	Mephenytoin-13C,d3 is a deuterated labeled Mephenytoin[1]. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[2].
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Mephenytoin-13C,d3 相关抗体:
In Vivo	Mephenytoin (口服给药，100 mg/kg，200 mg/kg) 在 200 mg/kg 时可减少母体体重增加并增加后代死亡率，但在 100 mg/kg 时不会在怀孕的 Sprague-Dawley CD 大鼠中产生过高的后代死亡率[3]。 Mephenytoin (腹腔注射，每天20mg/kg，连续16天) 显著降低小鼠血清胆固醇和甘油三酯水平，可能具有降血脂作用[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1261398-53-1
Formula	C1113CH11D3N2O2
Molar Mass	222.26
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. D R Minck, et al. Comparison of the behavioral teratogenic potential of phenytoin, mephenytoin, ethotoin, and hydantoin in rats. Teratology. 1991 Apr;43(4):279-93. [3]. Klaassen T, et al. Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity. Eur J Clin Pharmacol. 2008;64(4):387-398. [4]. J H Maguire, et al. Hypolipidemic activity of antiepileptic 5-phenylhydantoins in mice. Eur J Pharmacol. 1985 Oct 29;117(1):135-8.

(Rac)-PD 151746