| Bioactivity | Menthol-d2 is deuterated labeled trans-2,cis-6-Nonadienal (HY-W127515). Trans-2, cis-6-NonadienalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2, cis-6-NonadienalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Menthol-d2 相关抗体: |
| In Vivo | Menthol (10-200 μg/mL; po; 单剂量) 可以减少小鼠口服尼古丁 (200 μg/mL) 的厌恶作用，并且在较高浓度下，Menthol 本身会产生刺激物[3]。Menthol 还通过 TRPM8 可以强烈抑制呼吸道刺激反应，并且会增加血液中的可替宁。Menthol 作为卷烟添加剂，可能会促进吸烟和尼古丁成瘾[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 1335435-38-5 |
| Formula | C10H18D2O |
| Molar Mass | 158.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. NicolettaGaleotti, et al. Menthol: a natural analgesic compound. Neuroscience Letters. 2002 Apr. [3]. Ha MA, et al. Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice. PLoS One. 2015 Feb 13;10(2):e0117128. [4]. Fan L, et al. Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism. Tob Control. 2016 Nov;25(Suppl 2):ii50-ii54. |
Menthol-d2
CAS: 1335435-38-5 F: C10H18D2O W: 158.28
Menthol-d2 is deuterated labeled trans-2,cis-6-Nonadienal (HY-W127515). Trans-2, cis-6-NonadienalIt is an organic compou
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