Men 10376

CAS: 135306-85-3 F: C57H68N12O10 W: 1081.22

Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor

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Bioactivity	Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
Invitro	Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].
Name	Men 10376
CAS	135306-85-3
Sequence	Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2
Shortening	DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2
Formula	C57H68N12O10
Molar Mass	1081.22
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

trans-N-Methyl-4-methoxyproline