| Bioactivity | Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor[1]. | ||||||
| Invitro | Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2]. | ||||||
| Name | Men 10376 TFA | ||||||
| Sequence | Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2 | ||||||
| Shortening | DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2 | ||||||
| Formula | C59H69F3N12O12 | ||||||
| Molar Mass | 1195.25 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |