Melittin free acid_product_DataBase

Bioactivity	Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2].
Invitro	Melittin free acid 刺激小鼠纤维细胞 (MC5-5)、人成纤维细胞 (D550)、兔主动脉内皮细胞 (CLO)、大鼠肺型肺泡肺细胞 (L-2) 和兔平滑肌细胞 (R-I) 的前列腺素生物合成[1]。Melittin free acid 刺激 MC5-5 细胞磷脂中花生四烯酸的释放[1]。Melittin free acid 诱导黄曲霉萌发分生孢子中活性氧的积累[2]。Melittin 抑制灰霉菌 MUCL 30158 和 CECT 2100 菌株，IC50 值分别为 3.1 和 24 μM[2]。
Name	Melittin free acid
CAS	123168-46-7
Shortening	GIGAVLKVLTTGLPALISWIKRKRQQ
Formula	C131H228N38O32
Molar Mass	2847.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

PeptideDB