| Bioactivity | Melflufen (Melphalan flufenamide), a dipeptide prodrug of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells[1][2][3]. |
| Invitro | Melflufen (Melphalan flufenamide) (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner[1].Melflufen induces apoptosis in MM.1S cells[1].Melphalan also is a potent activator of exosome secretion[3]. Cell Viability Assay Cell Line: |
| Name | Melflufen |
| CAS | 380449-51-4 |
| Formula | C24H30Cl2FN3O3 |
| Molar Mass | 498.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Melflufen
CAS: 380449-51-4 F: C24H30Cl2FN3O3 W: 498.42
Melflufen (Melphalan flufenamide), a dipeptide prodrug of Melphalan, is an alkylating agent. Melflufen shows antitumor a
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