Melanin probe-1_product_DataBase

Bioactivity

Melanin probe-1 is an 18F-picolinamides based PET probe. Melanin probe-1 can be used for PET imaging of malignant melanoma. Melanin probe-1 exhibits high tumor targeting efficiency, excellent tumor imaging contrasts, desirable biodistribution patterns, and good in vivo stability[1].

In Vivo

Melanin probe-1 (3.7 MBq; tail vein) exhibits high tumor targeting efficiency[1].Melanin probe-1 shows high in vivo stability and favorable pharmacokinetic properties such as fast clearance from urinal system and almost background level of uptakes for all of the major organs at 2 h. The high selectivity and specificity of Melanin probe-1, as evidenced by the high tumor-to-non tumor ratios, highlight that Melanin probe-1 PET has high potential to improve the melanoma detection[1]. Animal Model:

Name

Melanin probe-1

CAS

1420844-62-7

Formula

C12H18FN3O

Molar Mass

239.29

Appearance

Oil

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Liu H, et al. Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma. J Med Chem. 2013;56(3):895‐901.

PeptideDB

Melanin probe-1

CAS: 1420844-62-7 F: C12H18FN3O W: 239.29