Meglumine (Excipient)

CAS: 6284-40-8 F: C7H17NO5 W: 195.21

Meglumine (Methylglucamine) (Excipient) is an orally active amino sugar derived from sorbitol. Meglumine(Excipient) has

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Meglumine (Methylglucamine) (Excipient) is an orally active amino sugar derived from sorbitol. Meglumine (Excipient) has anti-inflammatory and antitumor activity. Meglumine (Excipient) is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide[1][2][3].
Invitro	Meglumine (Excipient) (40 或 80 mM，24 h；50 mM, 24 h) 在 THP-1 人髓样细胞和 RAW264.7 小鼠巨噬细胞细胞中剂量依赖性降低炎症因子水平 (Elisa assay)[2]。Meglumine (Excipient) (0-300 mM, 60 min) 在 C2C12 小鼠成肌细胞中剂量依赖性的增加 SNARK 的表达水平[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Meglumine (Excipient) 相关抗体: Western Blot Analysis[4] Cell Line:
In Vivo	Meglumine (Excipient) (25 或 50 mM；37.5 mM, 溶解在水中口服) 在大鼠和小鼠中可减少炎症因子水平，抑制皮肤癌肿瘤生长[2]。Meglumine (Excipient) (18 mM, 口服) 在 Ⅱ 型糖尿病小鼠中可改善肌肉功能、限制代谢综合征和减少糖尿病并发症[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	6284-40-8
Formula	C7H17NO5
Molar Mass	195.21
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. de Souza ALR, et al. Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness. Colloids Surf B Biointerfaces. 2019 Dec 1;184:110523. [2]. Manley K, et al. Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine. J Cell Biochem. 2019 Jul;120(7):12051-12062. [3]. Guo R Y, et al. Meglumine promoted one-pot, four-component synthesis of pyranopyrazole derivatives. Tetrahedron, 2013, 69(47): 9931-9938. [4]. Bravo-Nuevo A, et al. Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes. PLoS One. 2014 Feb 27;9(2):e90031.

DSS Crosslinker-d4