| Bioactivity | Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway[1][2][3][4][5]. | ||||||||||||
| Invitro | Megestrol acetate alone results in an ICKY of 48.7 p,M in the MCF7/ADR cell line[2]. | ||||||||||||
| In Vivo | Megestrol acetate (100 or 300 mg/kg, Subcutaneously daily over a 7-day period) is able to reduce the weight loss produced by both TNF and by the MAC16 tumour[1]. Animal Model: | ||||||||||||
| Name | Megestrol acetate | ||||||||||||
| CAS | 595-33-5 | ||||||||||||
| Formula | C24H32O4 | ||||||||||||
| Molar Mass | 384.51 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. S A Beck, et al. Effect of megestrol acetate on weight loss induced by tumour necrosis factor alpha and a cachexia-inducing tumour (MAC16) in NMRI mice. Br J Cancer. 1990 Sep;62(3):420-4. [2]. L Panasci, et al. Sensitization to doxorubicin resistance in breast cancer cell lines by tamoxifen and megestrol acetate. Biochem Pharmacol. 1996 Oct 11;52(7):1097-102. [3]. J Geller, et al. Acute therapy with megestrol acetate decreases nuclear and cytosol androgen receptors in human BPH tissue. Prostate. 1982;3(1):11-5. [4]. J H von Roenn, et al. Megestrol acetate for treatment of cachexia associated with human immunodeficiency virus (HIV) infection. Ann Intern Med. 1988 Nov 15;109(10):840-1. [5]. Vincenzo Musolino, et al. Megestrol acetate improves cardiac function in a model of cancer cachexia-induced cardiomyopathy by autophagic modulation. J Cachexia Sarcopenia Muscle. 2016 Dec;7(5):555-566. |
Megestrol acetate
CAS: 595-33-5 F: C24H32O4 W: 384.51
Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite st
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