| Bioactivity | MeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC50=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC50=11.2 μM). MeIm can be used in the study of cardiovascular diseases[1][2]. |
| CAS | 2043947-71-1 |
| Formula | C22H22N8 |
| Molar Mass | 398.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024): 13. [2]. Stucchi, et al. "Disrupting the PCSK9/LDLR protein–protein interaction by an imidazole-based minimalist peptidomimetic." Organic & Biomolecular Chemistry 14.41 (2016): 9736-9740. |