| Bioactivity | MeIQx, a dietary aromatic amine, is mutagenic compound could be isolated from present in fried beef and beef extracts. MeIQx binds covalently to hemoglobin. MeIQx induces liver tumors[1][2]. |
| Invitro | MeIQx (0.47 mM; 0-120 min) binds covalently to mouse hemoglobin and is activated by mouse microsomes to metabolites[1]. |
| In Vivo | MeIQx (2.0-200 mg/kg; i.p.; male Swiss Webster mice) is in the covalent binding to hemoglobin in a dose-dependent manner[1]. Animal Model: |
| Name | MeIQx |
| CAS | 77500-04-0 |
| Formula | C11H11N5 |
| Molar Mass | 213.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lynch AM, et, al. The measurement of MeIQx adducts with mouse haemoglobin in vitro and in vivo: implications for human dosimetry. Carcinogenesis. 1991 Jun;12(6):1067-72. [2]. Ohgaki H, et, al. Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods. 1987 May;8(5):665-8. |